Monday, November 10, 2008

Phosphorylation of LRRK2: Functional characterization

The poster in SFN on the above topic by G. Ito et al talks about the N-terminal Serine residues (Ser 910 and Ser 973). The authors claimed in the abstract that mutating these residues did not alter the Kinase of GTPase activity of the protein. What it appears to me that these residues might not be the ones which governs the Kinase or GTPase activity in PD-related patients. I will look forward for more results in the meeting.

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