A recent review article by Cookson et al have pointed out 3 prominent questions about LRRK2. These are some burning issues and answers to these questions would lay the fundamental foundation stone in understanding the LRRK2 biology at the molecular level in a better way. It will also help in designing therapeutics for LRRK2, which itself has been a good kinase target.
The 3 questions that the authors fundamentally wish to address are:
1. What is the normal function of LRRK2.
2. How mutations impact LRRk2 function.
3. Possible mechanisms of LRRK2 mediated neurotoxicity.
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